Innovations in Tuberculosis Diagnosis and Therapy
Tuberculosis (TB) remains one of the top infectious disease killers globally, despite significant advancements in prevention and treatment over the past century. However, challenges such as drug-resistant TB, long treatment regimens, and delayed diagnosis continue to hinder efforts to control and eliminate the disease. The development of rapid molecular tests, such as nucleic acid amplification tests (NAATs), which have revolutionized TB diagnosis by providing faster and more accurate results compared to traditional sputum microscopy. Innovations in imaging techniques, including advanced radiographic methods and artificial intelligence (AI)-based interpretation systems, will also be explored as tools to improve diagnosis, particularly in resource-limited settings. New antibiotic candidates, such as bedaquiline and delamanid, will be discussed, along with novel treatment combinations and strategies to shorten the treatment duration for drug-sensitive TB.Additionally,this will address the role of vaccine development in the fight against TB, including progress with candidates such as the M72/AS01E vaccine and other novel vaccine approaches aimed at both prevention and treatment.
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